期刊
BLOOD
卷 114, 期 3, 页码 719-722出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2009-02-204750
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类别
资金
- Region Pays de Loire
- Association pour la Recherche sur le Cancer
- Fondation de France
- Fondation contre la Leucemie
- Agence de Biomedecine
- Association Cent pour Sang la Vie
- Association Laurette Fuguain
Imatinib is a promising candidate for the treatment of fibrotic diseases. This retrospective study evaluated the use of imatinib for the treatment of refractory sclerotic chronic graft-versus-host disease in 14 patients with different hematologic malignancies. Imatinib was started at a median of 44 months after transplantation (range, 16-119 months after transplantation) and was administered for a median of 5.9 months from time of initiation range, 2.1-74 months from time of initiation). With a median overall follow-up of 11.6 months from time of initiation (range, 4.1-74 months from time of initiation) of imatinib, 4 patients (29%) had to stop imatinib because of drug intolerance. All other adverse reactions were of mild-tomoderate grade and could be managed symptomatically. Overall, 7 patients responded to imatinib (50%; 95% confidence interval, 24%-76%) with 4 patients improving their Rodman score more than or equal to 90%. In addition, imatinib therapy allowed for a significant reduction of corticosteroid dosage. Despite its limited size, this cohort suggests some beneficial activity of imatinib in sclerotic chronic graft-versus-host disease, warranting further prospective investigations. (Blood. 2009;114:719-722)
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