期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 4, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2016.00130
关键词
diacylglycerol kinase; regulatory T cells; invariant NKT cells
资金
- National Institutes of Health [R01AI079088, R01 AI101206]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI101206, R01AI079088] Funding Source: NIH RePORTER
Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. Both DAG and PA are important second messengers cascading T cell receptor (TCR) signal by recruiting multiple effector molecules, such as RasGRP1, PKC theta, and mTOR. Studies have revealed important physiological functions of DGKs in the regulation of receptor signaling and the development and activation of immune cells. In this review, we will focus on recent progresses in our understanding of two DGK isoforms, alpha and zeta, in CD8 T effector and memory cell differentiation, regulatory T cell development and function, and invariant NKT cell development and effector lineage differentiation.
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