期刊
BLOOD
卷 112, 期 3, 页码 461-469出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2007-09-077438
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资金
- NCI NIH HHS [U10 CA101140, R01 CA068458, P01 CA095426, P30 CA016058, CA89341, CA95426, R37 CA068458, CA16058, CA101140, CA68458, R01 CA089341] Funding Source: Medline
Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that belong to the innate immune system because unlike T or B lymphocytes of the adaptive or antigen-specific immune system, NK cells do not rearrange T-cell receptor or immunoglobulin genes from their germline configuration. During the past 2 decades there has been a substantial gain in our understanding of what and how NK-cells see, lending important insights into their functions and purpose in normal immune surveillance. The most recent discoveries in NK-cell receptor biology have fueled translational research that has led to remarkable results in treating human malignancy.
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