期刊
BLOOD
卷 113, 期 9, 页码 1977-1981出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-08-174094
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- Medical Research Council [G0801924] Funding Source: Medline
- MRC [G0801924] Funding Source: UKRI
- Medical Research Council [G0801924, G9900991B] Funding Source: researchfish
Dendritic cells (DCs) are known to secrete exosomes that transfer membrane proteins, like major histocompatibility complex class II, to other DCs. Intercellular transfer of membrane proteins is also observed during cognate interactions between DCs and CD4(+) T cells. The acquired proteins are functional and play a role in regulation of immune responses. How membrane protein transfer is achieved and regulated is unclear. Here we show that T cells can recruit major histocompatibility complex class II containing DC exosomes secreted in the extracellular milieu during cognate DC T-cell interactions. Recruitment of these exosomes required T-cell activation and was dependent on leukocyte function associated antigen-1 (LFA-1) rather than on T-cell receptor specificity. Indeed, inducing a high-affinity state of LFA-1 on resting T cells was sufficient to provoke exosome binding. These results imply that DC exosomes secreted in the extracellular milieu during cognate T-cell-DC interactions are targeted to T cells activated in that microenvironment. (Blood. 2009; 113: 1977-1981)
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