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注意：仅列出部分参考文献，下载原文获取全部文献信息。Pyrimethamine treatment does not ameliorate lymphoproliferation or autoimmune disease in MRL/Ipr-/- mice or In patients with autoimmune lymphoproliferative syndrome
V. Koneti Rao et al.
AMERICAN JOURNAL OF HEMATOLOGY (2007)
The novel γ secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the TG2576 mouse
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Notch1 and its ligand Jagged1 are present in remyelination in a T-cell- and antibody-mediated model of inflammatory demyelination
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ACTA NEUROPATHOLOGICA (2007)
Arsenic trioxide:: a promising novel therapeutic agent for lymphoproliferative and autoimmune syndromes in MRL/lpr mice
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Notch signaling in cancer
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CURRENT MOLECULAR MEDICINE (2006)
Studies to investigate the in vivo therapeutic window of the γ-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse
Lynn A. Hyde et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling
Hassen Kared et al.
IMMUNITY (2006)
B cell depletion therapy in systemic lupus erythematosus - Effect on autoantibody and antimicrobial antibody profiles
G. Cambridge et al.
ARTHRITIS AND RHEUMATISM (2006)
The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor
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JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)
David T. Teachey et al.
BLOOD (2006)
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
C Grabher et al.
NATURE REVIEWS CANCER (2006)
The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
DT Teachey et al.
BLOOD (2006)
Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive protein
W Rodriguez et al.
ARTHRITIS AND RHEUMATISM (2006)
Inhibition of Notch signaling enhances tissue repair in an animal model of multiple sclerosis
M Jurynczyk et al.
JOURNAL OF NEUROIMMUNOLOGY (2005)
Amelioration of autoimmune nephritis by imatinib in MRL/lpr mice
A Sadanaga et al.
ARTHRITIS AND RHEUMATISM (2005)
Acute γ-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease
TA Comery et al.
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Animal models of spontaneous and drug-induced cutaneous lupus erythematosus
F Furukawa et al.
AUTOIMMUNITY REVIEWS (2005)
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
JH van Es et al.
NATURE (2005)
Use of mycophenolate mofetil for chronic, refractory immune cytopenias in children with autoimmune lymphoproliferative syndrome
VK Rao et al.
BRITISH JOURNAL OF HAEMATOLOGY (2005)
Isolation and characterization of human antigen-specific TCRαβ+ CD4-CD8- double-negative regulatory T cells
K Fischer et al.
BLOOD (2005)
Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS)
DT Teachey et al.
BLOOD (2005)
gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease
I Churcher et al.
CURRENT PHARMACEUTICAL DESIGN (2005)
Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
GT Wong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations
S Poppema et al.
LEUKEMIA & LYMPHOMA (2004)
Modulation of renal disease in MRL/lpr mice by suberoylanilide hydroxamic acid
CM Reilly et al.
JOURNAL OF IMMUNOLOGY (2004)
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
AP Weng et al.
SCIENCE (2004)
Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells
Y Maekawa et al.
IMMUNITY (2003)
Notch signaling augments T cell responsiveness by enhancing CD25 expression
SH Adler et al.
JOURNAL OF IMMUNOLOGY (2003)
Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice
H Hasegawa et al.
ARTHRITIS AND RHEUMATISM (2003)
Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways
F Rieux-Laucat et al.
CELL DEATH AND DIFFERENTIATION (2003)
Dominant expression of interleukin 10 but not interferon γ in CD4-CD8- αβT cells of autoimmune lymphoproliferative syndrome
S Ohga et al.
BRITISH JOURNAL OF HAEMATOLOGY (2002)
Genetic dissection of SLE:: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity
XY Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
A composite picture of TcRα/β+ CD4-CD8- T cells (α/β-DNTCs) in humans with autoimmune lymphoproliferative syndrome
JJH Bleesing et al.
CLINICAL IMMUNOLOGY (2002)
Inactivation of Notch2 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes
A Wolfer et al.
IMMUNITY (2002)
Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations
JV ten Bosch et al.
BRITISH JOURNAL OF HAEMATOLOGY (2002)
Characterization of CD3(+)CD4(-)CD8(-) (double negative) T cells in patients with systemic lupus erythematosus: production of IL-4
GS Dean et al.
LUPUS (2002)
TcR-α/β+ CD4-CD8- T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis
JJH Bleesing et al.
CLINICAL IMMUNOLOGY (2001)
Murine models of systemic lupus erythematosus:: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Faslpr and (NZB x NZW)F1 lupus mice
F Monneaux et al.
INTERNATIONAL IMMUNOLOGY (2001)
Autoimmune lymphoproliferative syndrome - A human disorder of abnormal lymphocyte survival
JJH Bleesing et al.
PEDIATRIC CLINICS OF NORTH AMERICA (2000)
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