期刊
BLOOD
卷 111, 期 11, 页码 5271-5281出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2008-01-078204
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资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL066105, R37HL041002, R01HL069438, P01HL056949] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI069402] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK056638] Funding Source: NIH RePORTER
- NHLBI NIH HHS [P01 HL056949, P01 HL066105, R01 HL69438, R01 HL069438, R37 HL041002] Funding Source: Medline
- NIAID NIH HHS [R01 AI069402] Funding Source: Medline
- NIDDK NIH HHS [R01 DK056638] Funding Source: Medline
Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western world. In this review, we relate the history of blood cell interactions with the vasculature, discuss recent progress, and raise some unresolved questions awaiting the field.
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