期刊
BLOOD
卷 111, 期 7, 页码 3540-3545出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2007-11-122945
关键词
-
类别
资金
- Telethon [GGP030453] Funding Source: Medline
ABO blood groups greatly influence circulating von Willebrand factor (VWF) levels, and 0 group subjects have lower VWF values. In this study, we investigated whether ABO groups affect VWF survival by monitoring the post-DDAVP (1-desamino-8-d arginine vasopressin) time courses of VWF antigen (VWF:Ag), VWF collagen binding (VWF:CB), and factor VIII (FVIII) in 47 healthy subjects (28 0 and 19 non-O blood groups). The elimination half-life (T(1/2)el) of VWF was found significantly shorter in O than in non-O subjects (10.0 +/- 0.8 hours vs 25.5 +/- 5.3 hours, respectively; P <.01), as was the T(1/2)el of VWF:CB (7.9 +/- 0.5 hours vs 20.9 +/- 4.5 hours; P <.01). A direct linear correlation was found between basal VWF:Ag and T(1/2)el, subjects with higher VWF levels having longer-surviving VWF. ABO blood groups appeared to strongly influence VWF clearance, but not its synthesis or release from endothelial cells. The VWF propeptide to VWF:Ag ratio, useful for predicting an increased VWF clearance, was found significantly higher in O than in non-O individuals (1.6 +/- 0.1 vs 1.2 +/- 0.5, P <.001), with values that correlated inversely with T(1/2)el (P <.001). Based on these findings, we conclude that the lower VWF values in O group individuals is attributable to a shorter VWF survival and circulating VWF values are strongly influenced by its half-life.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据