Toward production of pure C-13 hyperpolarized metabolites using heterogeneous parahydrogen-induced polarization of ethyl[1-C-13]acetate

Here, we report the production of C-13-hyperpolarized ethyl acetate via heterogeneously catalyzed pairwise addition of parahydrogen to vinyl acetate over TiO2-supported rhodium nanoparticles, followed by magnetic field cycling. Importantly, the hyperpolarization is demonstrated even at the natural abundance of C-13 isotope (ca. 1.1%) along with the easiest separation of the catalyst from the hyperpolarized liquid.