Synthesis of 2,3-dihydroquinazolinones and quinazolin-4(3H)-ones catalyzed by graphene oxide nanosheets in an aqueous medium: on-water synthesis accompanied by carbocatalysis and selective C-C bond cleavage

Graphene oxide (GO) nanosheet catalyzed new and straightforward strategies for the construction of 2,3-dihydroquinazolinones and quinazolin-4(3H)-ones starting from anthranilamide (2-aminobenzamide) and an aldehyde/ketone in aqueous medium at room temperature have been realized. This catalyst is also found to be efficient for the expedient construction of quinazolin-4(3H)-ones starting from anthranilamide and a beta-ketoester/1,3-diketone following selective C-C bond cleavage of the beta-ketoester/1,3-diketone at an elevated temperature under metal and oxidant free conditions.