期刊
BLOOD
卷 112, 期 3, 页码 672-679出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2007-10-116269
关键词
-
类别
资金
- MRC [G0501074] Funding Source: UKRI
- Medical Research Council [G0501074, G9818340B] Funding Source: researchfish
- Cancer Research UK Funding Source: Medline
- Medical Research Council [G0501074] Funding Source: Medline
Epstein-Barr virus (EBV) persists in healthy virus carriers within the immunoglobulin (Ig)D-CD27+ (class-switched) memory B-cell compartment that normally arises through antigen stimulation and germinal center transit. Patients with X-linked lymphoproliferative disease (XLP) lack such class-switched memory B cells but are highly susceptible to EBV infection, often developing fatal symptoms resembling those seen in EBVassociated hemophagocytic syndrome (EBV-AHS), a disease caused by aberrant virus entry into the NK- or T-cell system. Here we show that XLP patients who survive primary EBV exposure carry relatively high virus loads in the B-cell, but not the NK- or T-cell, compartment. Interestingly, in the absence of conventional class-switched memory B cells, the circulating EBV load was concentrated within a small population of IgM+IgD+CD27+ (nonswitched) memory cells rather than within the numerically dominant naive (IgM+IgD+CD27-) or transitional (CD10+CD27-) subsets. In 2 prospectively studied patients, the circulating EBV load was stable and markers of virus polymorphism detected the same resident strain over time. These results provide the first definitive evidence that EBV can establish persistence in the Bcell system in the absence of fully functional germinal center activity and of a class-switched memory B-cell compartment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据