期刊
BJU INTERNATIONAL
卷 113, 期 5, 页码 789-794出版社
WILEY-BLACKWELL
DOI: 10.1111/bju.12571
关键词
idiopathic retention; Interstim (TM); voiding dysfunction; lower urinary tract dysfunction; overactive bladder; sacral neuromodulation; Fowler's syndrome; urgency frequency syndrome; urgency incontinence
资金
- Allergan
- Astellas
- BARD
- Medtronic
Objective To report our long-term experience of sacral neuromodulation (SNM) for various lower urinary tract dysfunctions but with a focus on efficacy, safety, re-interventions and degree of success. Patients and Methods This is a single tertiary referral centre study that included 217 patients (86% female) who received an implantable pulse generator (IPG) (Interstim (TM), Medtronic, Minneapolis, USA) between 1996 and 2010. Success was considered if the initial >= 50% improvement in any of primary voiding diary variables persisted compared with baseline, but was further stratified. Results The mean duration of follow-up was 46.88 months. Success and cure rates were approximate to 70% and 20% for urgency incontinence, 68% and 33% for urgency frequency syndrome and 73% and 58% for idiopathic retention. In those patients with an unsuccessful therapy outcome, the mean time to failure was 24.6 months after implantation. There were 88 (41%) patients who had at least one device or treatment related surgical re-intervention. The re-intervention rate was 1.7 per patient with most of them (47%) occurring <= 2 years of follow-up. Conclusions SNM appears effective in the long-term with a success rate after definitive IPG implant of approximate to 70% and complete cure rates ranging between 20% and 58% depending on indication. Patients with idiopathic retention appear to do best. The re-intervention rate is high with most occurring <= 2 years of implantation. It is likely that with the newer techniques used, efficacy and re-intervention rates will improve.
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