期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2016.00041
关键词
Salmonella RpoN regulon; sigma 54; bacterial enhancer-binding protein; bEBP; transcription activation; stress adaptation
资金
- NSF [MCB-1051175]
- NIH [R21 AI117102-01A1]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI117102] Funding Source: NIH RePORTER
Transcription sigma factors direct the selective binding of RNA polymerase holoenzyme (E sigma) to specific promoters. Two families of sigma factors determine promoter specificity, the sigma(70) (RpoD) family and the sigma(54) (RpoN) family. In transcription controlled by sigma(54), the E sigma(54)-promoter closed complex requires ATP hydrolysis by an associated bacterial enhancer-binding protein (bEBP) for the transition to open complex and transcription initiation. Given the wide host range of Salmonella enterica serovar Typhimurium, it is an excellent model system for investigating the roles of RpoN and its bEBPs in modulating the lifestyle of bacteria. The genome of S. Typhimurium encodes 13 known or predicted bEBPs, each responding to a unique intracellular or extracellular signal. While the regulons of most alternative sigma factors respond to a specific environmental or developmental signal, the RpoN regulon is very diverse, controlling genes for response to nitrogen limitation, nitric oxide stress, availability of alternative carbon sources, phage shock/envelope stress, toxic levels of zinc, nucleic acid damage, and other stressors. This review explores how bEBPs respond to environmental changes encountered by S. Typhimurium during transmission/infection and influence adaptation through control of transcription of different components of the S. Typhimurium RpoN regulon.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据