期刊
GUT MICROBES
卷 7, 期 2, 页码 171-177出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2016.1155021
关键词
bacteria-mediated tumor therapy; LPS; Lipid A; Salmonella Typhimurium; UK-1
资金
- Hannover Biomedical Research School, Center for Infection Biology program (ZIB)
- SymbioPharm GmbH
- Ph.D. program Zoonosis by a Lichtenberg Fellowship from the Niedersachsische Ministerium fur Wissenschaft und Kultur (MWK)
Bacteria-mediated tumor therapy using Salmonella enterica serovar Typhimurium is a therapeutic option with great potential. Numerous studies explored the potential of Salmonella Typhimurium for therapeutic applications, however reconciling safety with vectorial efficacy remains a major issue. Recently we have described a conditionally attenuated Salmonella vector that is based on genetic lipopolysaccharide modification. This vector combines strong attenuation with appropriate anti-tumor properties by targeting various cancerous tissues in vivo. Therefore, it was promoted as an anti-tumor agent. In this addendum, we summarize these findings and demonstrate additional optimization steps that may further improve the therapeutic efficacy of our vector strain.
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