期刊
GUT MICROBES
卷 7, 期 6, 页码 526-532出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2016.1239677
关键词
colon; colonization; fibrinogen; MUC2; MUC5AC; mucins; Pil3 pilus; S.bovis; S.gallolyticus
Streptococcus gallolyticus is a commensal bacterium responsible for infectious endocarditis in the elderly, which has frequently been associated with colonic carcinoma. Whether this species is a cause or a consequence of colorectal cancer remains unknown. We recently demonstrated that S. gallolyticus Pil3 pilus is required for adhesion to colonic mucus and for colonization of mouse distal colon. We show here that Pil3 pilus binds equally well to human colonic mucins derived from HT29-MTX cells and to human stomach mucins from healthy donors. In addition, we have found that Pil3 also binds to human fibrinogen, which expands the repertoire of Pil3 host ligands.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据