期刊
MOLECULAR SYSTEMS DESIGN & ENGINEERING
卷 1, 期 3, 页码 225-241出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6me00031b
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资金
- National Science Foundation [DMR1411320]
- University of Colorado Liquid Crystal Material Research Center [NSF DMR0820579]
Photonic crystals embedded in analyte responsive hydrogels provide a powerful platform for biosensing and have benefitted from recent advances in polymer synthesis and functionalization, nanofabrication, and optical characterization. In this review, state-of-the-art techniques for the fabrication and functionalization of photonic crystal hydrogels are presented, along with a fundamental description of how such materials transduce detection of a target analyte into a simple optical readout. Specific biosensing applications using photonic crystal hydrogels are highlighted, including for the detection of DNA hybridization and single-site DNA modifications, enzyme activity, and small molecule metabolites. Moreover, perspectives on using molecular-level interactions to design and engineer more sensitive or more selective biosensors, as well as future directions in this expanding field, are discussed.
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