期刊
TRANSCRIPTION-AUSTIN
卷 7, 期 4, 页码 115-120出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21541264.2016.1188873
关键词
decoy; regulatory elements; sequestration; target search; transcription factors
资金
- National Institutes of Health [R01-GM107590, R01-GM105931]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM107590, R01GM105931] Funding Source: NIH RePORTER
Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors.
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