期刊
BREAST CANCER-TARGETS AND THERAPY
卷 8, 期 -, 页码 73-82出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/BCTT.S97963
关键词
breast cancer; bone metastases; hormone receptor-positive; bone-related complications; interventions; management and management strategies; estrogen receptor-positive
类别
资金
- Novartis Pharmaceuticals Corporation
There is a high risk for bone loss and skeletal-related events, including bone meta-s-tases, in postmenopausal women with hormone receptor-positive breast cancer. Both the disease itself and its therapeutic treatments can negatively impact bone, resulting in decreases in bone mineral density and increases in bone loss. These negative effects on the bone can significantly impact morbidity and mortality. Effective management and minimization of bone-related complications in postmenopausal women with hormone receptor-positive breast cancer remain essential. This review discusses the current understanding of molecular and biological mechanisms involved in bone turnover and metastases, increased risk for bone-related complications from breast cancer and breast cancer therapy, and current and emerging treatment strategies for managing bone metastases and bone turnover in postmenopausal women with hormone receptor-positive breast cancer.
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