期刊
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
卷 122, 期 6, 页码 785-794出版社
WILEY
DOI: 10.1111/1471-0528.12994
关键词
Candida albicans; immunity; pathogenesis; vaccines; vulvovaginal candidiasis
资金
- special research programs ISS-Ministry of Health (Italy) on AIDS and Opportunistic Infections
Although a number of fungal species belonging to the genus Candida can cause acute vulvovaginal infection (VVC), Candida albicans is by far the most prevalent etiological agent, particularly for the most severe chronic condition known as recurrent vulvovaginal candidiasis (RVVC). This review focuses on recent advances in pathogenic mechanisms and host immune responses to C.albicans and on the utilisation of this information in the development of a vaccine to prevent and/or treat vaginal candidiasis. Currently, two vaccines with main or sole RVVC as clinical indication have completed a phase 1 clinical trial, and one of them has entered a phase 2 trial.
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