期刊
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
卷 120, 期 11, 页码 1413-1422出版社
WILEY-BLACKWELL
DOI: 10.1111/1471-0528.12370
关键词
Anorexia nervosa; bulimia nervosa; growth development; head circumference; offspring
资金
- Swedish Research Council [20324]
- Stockholm County Council
- Karolinska Institutet, Stockholm, Sweden
ObjectiveTo characterise early growth and neurocognitive development in children of mothers with a history of eating disorders (ED). DesignA longitudinal cohort study. SettingChild-care centres in Stockholm, Sweden. PopulationChildren born to mothers with previous ED (n=47) (24 anorexia nervosa, 20 bulimia nervosa, 3 unspecified ED), and controls (n=65). MethodsMean values and standard deviation scores of weight and height from birth to 5years of age and head circumference up to 18months of age were compared between groups. Neurocognitive development was studied at the age of 5years by the validated parent questionnaire Five to Fifteen. Main outcome measuresHead growth and neurocognitive development. ResultsWe previously reported that mothers with a history of ED conceived infants with lower birthweight and head circumference than controls. At 3months of age, body mass index (BMI) was no longer reduced but mean head circumferences of the children born to mothers with ED were smaller throughout the observation period. Similarly, the longitudinal results of the standard deviation scores of head circumference showed a significant overall group effect with lower levels in both subgroups of ED (anorexia nervosa and bulimia nervosa). The children of the ED mothers also had significantly higher Five to Fifteen scores than controls, reflecting difficulties in language skills. Head circumference at birth correlated with language skills in the children of mothers with ED. ConclusionChildren of mothers with previous ED demonstrated an early catch-up in BMI, but the average head circumference continued to be delayed until at least 18months of age. The reduced head growth was related to delayed neurocognitive development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据