期刊
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
卷 118, 期 8, 页码 936-944出版社
WILEY
DOI: 10.1111/j.1471-0528.2011.02952.x
关键词
Embolisation; fibroids; leiomyoma
资金
- Scottish Government, Chief Scientist Office
- University of Glasgow
- Chief Scientist Office, The Scottish Government, St Andrews House, Regent Road, Edinburgh, UK [EH1 3DG]
- MRC [G0800803] Funding Source: UKRI
- Chief Scientist Office [CZB/4/484] Funding Source: researchfish
- Medical Research Council [G0800803] Funding Source: researchfish
Objective To compare the long-term results of uterine artery embolisation (UAE) with surgery for women with symptomatic uterine fibroids. Design Pragmatic, open, multicentre, randomised trial. Setting Twenty-seven participating UK secondary care centres. Sample Women aged >= 18 years with symptomatic fibroids who were considered to justify surgical treatment Methods In total, 157 women were randomised (in a 2:1 ratio): 106 to UAE and 51 to surgery (hysterectomy 42; myomectomy nine). Main outcome measures Quality of life at 5 years, as assessed by the Short Form General Health Survey (SF-36). Secondary measures included complications, adverse events and the need for further intervention. Results There were no significant differences between groups in any of the eight components of the SF-36 scores at 5 years (minimum P = 0.45). Symptom score reduction and patient satisfaction with either treatment was very high, with no group difference. Rates of adverse events were similar in both groups (19% embolization and 25% surgery; P = 0.40). The 5-year intervention rate for treatment failure or complications was 32% (UAE arm) and 4% (surgery arm), respectively. The initial cost benefit of UAE over surgery at 12 months was substantially reduced because of subsequent interventions, with treatments being cost neutral at 5 years. Conclusions We have found that UAE is a satisfactory alternative to surgery for fibroids. The less invasive nature of UAE needs to be balanced against the need for re-intervention in almost a third of patients. The choice should lie with the informed patient.
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