期刊
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
卷 118, 期 2, 页码 136-144出版社
WILEY
DOI: 10.1111/j.1471-0528.2010.02728.x
关键词
Infection; nonhuman primate; preterm labour
资金
- March of Dimes
- National Institutes of Health [HD06159, HD18185, HD01264, HD41676, RR00163, AI42490, AI067910]
- Proteogenix, Inc.
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K12HD001264] Funding Source: NIH RePORTER
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD041676, P30HD018185, R01HD006159, U54HD018185, R37HD006159] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [K01RR000163, UL1RR025014, P51RR000163] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI042490, K08AI067910] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [P51OD010425] Funding Source: NIH RePORTER
Preterm birth is the most important direct cause of neonatal mortality and remains a major challenge for obstetrics and global health. Intrauterine infection causes approximately 50% of early preterm births. Animal models using pregnant mice, rabbits or sheep demonstrate the key link between infection and premature birth, but differ in the mechanisms of parturition and placental structure from humans. The nonhuman primate (NHP) is a powerful model which emulates many features of human placentation and parturition. The contributions of the NHP model to preterm birth research are reviewed, emphasising the role of infections and the potential development of preventative and therapeutic strategies.
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