期刊
BIOMATERIALS
卷 112, 期 -, 页码 164-175出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.10.024
关键词
Copper bismuth sulfide; Nanorods; The second near-infrared (NIR-II) window; Multimodel imaging; Thermoradiotherapy
资金
- National Natural Science Foundation of China [81371645]
- Science and Technology Committee of Shanghai [15PJD020, 15441905800, 16JC1400604]
- Medicine & Engineering Cross Research Foundation of Shanghai Jiao Tong University [YG2014MS33]
In this work, we report a successful synthesis of copper bismuth sulfide nanorods (NRs) with broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, which can be used as a 1064 nm-laser-driven photothermal agent with the photothermal conversion efficiency of 40.7%, noticeably higher than most of the reported FIT agents working in NIR-II window. The as prepared PEGylated Cu3BiS3 NRs were used as photoacoustic imaging (PAD and CT imaging agents due to their strong NIR absorption and large X-ray attenuation coefficient of bismuth. We are the first to demonstrate that a small quantity of PEGylated Cu3BiS3 NRs in tumors can concentrate radiation energy and trigger mild PTT under NIR-II irradiation and thus, these particles could be used as a novel, synergistic thermoradiotheraputic agent that enhances the efficacy of radiotherapy. (C) 2016 Elsevier Ltd. All rights reserved.
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