期刊
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
卷 116, 期 7, 页码 964-974出版社
WILEY
DOI: 10.1111/j.1471-0528.2009.02150.x
关键词
Antioxidants; pre-eclampsia; prevention; vitamin C; vitamin E
资金
- The Danish Hospital Foundation for Medical Research
- Copenhagen Medical Society
- The University of Copenhagen
- Nutrition Group of the Danish National Birth Cohort
- March of Dimes Birth Defects Foundation [6-FY-96-0240, 6-FY97-0553, 6-FY97-0521, 6-FY00-407]
- EU [QLK1-CT-2000-00083]
- Danish National Re-search Foundation
- Danish Medical Research Council [9601842, 22-03-0536]
- Danish Health Foundation [11/263-96]
- Danish Heart Foundation [96-2-4-83-22450]
- DNBC
- Danish National Research Foundation
- Pharmacy Foundation
- Egmont Foundation
- Augustinus Foundation
It has been suggested that vitamin C, alone or in combination with vitamin E, may protect against pre-eclampsia, whereas the safety of high-dose vitamin E supplements has been questioned. We investigated dietary intakes of vitamins C and E to see if they correlated with the incidence of pre-eclampsia. Prospective cohort study. The Danish National Birth Cohort; a population-based pregnancy cohort; analyses were based on 57 346 pregnancies. Vitamin intake was estimated from a food frequency questionnaire completed in gestational week 25, recording intake from diet and supplements during the previous four weeks. Pre-eclampsia diagnoses were obtained from the Danish National Patient Registry; we worked with two entities, 'pre-eclampsia (all types)' and 'severe pre-eclampsia/eclampsia/HELLP'. We adjusted for confounding factors by logistic regression. A small increase in the incidence of severe disease was also seen in the group of women (64, n = 49 373) with a high intake of vitamin E from supplements and dietary sources. The incidence of 'pre-eclampsia (all types)' did not correlate with dietary vitamin C and E intake. There was a decreasing trend (P = 0.01) in the incidence of 'severe pre-eclampsia/eclampsia/HELLP' with increasing dietary vitamin C intake; with an intake of 130-170 mg/day as reference, odds ratios ranged from 1.21 (95% confidence interval 0.83 to 1.75) for an intake below 70 mg/day to 0.70 (0.40 to 1.23) for an intake exceeding 275 mg/day (total n = 57 346). For vitamin E intake aggregated from diet and supplements (n = 49 373), with an intake of 10.5-13.5 mg/day as reference, the 'severe pre-eclampsia/eclampsia/HELLP' odds ratio was 1.46 (1.02 to 2.09) for an intake exceeding 18 mg/day. Low dietary intake of vitamin C was associated with a trend towards an increased incidence of either severe pre-eclampsia, eclampsia or HELLP. A small increase in the incidence of severe disease was also seen in the group of women with a high intake of vitamin E from supplements and dietary sources.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据