期刊
BRAIN
卷 140, 期 -, 页码 387-398出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/aww296
关键词
multiple sclerosis; magnetization transfer ratio; normal-appearing white matter
资金
- MS Society of Great Britain and Northern Ireland
- Grant Charity of the Freemason's
- Karol Wojtila Association (Lavagna, Italy)
- National Institute for Health Research University College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative) [BW.mn.BRC10269]
- EPSRC [EP/H046410/1, EP/J020990/1, EP/K005278]
- MRC [MR/J01107X/1]
- NIHR Biomedical Research Unit (Dementia) at UCL
- NIHR BRC UCLH/UCL [BW.mn.BRC10269]
- Neurological Foundation of New Zealand
- United Kingdom Multiple Sclerosis Society
- National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre
- EPSRC [EP/I027084/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I027084/1, EP/H046410/1, EP/J020990/1] Funding Source: researchfish
- Medical Research Council [MR/J01107X/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10058] Funding Source: researchfish
In established multiple sclerosis, tissue abnormality-as assessed using magnetization transfer ratio-increases close to the lateral ventricles. We aimed to determine whether or not (i) these changes are present from the earliest clinical stages of multiple sclerosis; (ii) they occur independent of white matter lesions; and (iii) they are associated with subsequent conversion to clinically definite multiple sclerosis and disability. Seventy-one subjects had MRI scanning a median of 4.6 months after a clinically isolated optic neuritis (49 females, mean age 33.5 years) and were followed up clinically 2 and 5 years later. Thirty-seven healthy controls (25 females, mean age 34.4 years) were also scanned. In normal-appearing white matter, magnetization transfer ratio gradients were measured 1-5mm and 6-10mm from the lateral ventricles. In control subjects, magnetization transfer ratio was highest adjacent to the ventricles and decreased with distance from them; in optic neuritis, normal-appearing white matter magnetization transfer ratio was lowest adjacent to the ventricles, increased over the first 5 mm, and then paralleled control values. The magnetization transfer ratio gradient over 1-5mm differed significantly between the optic neuritis and control groups [+0.059 percentage units/mm (pu/mm) versus -0.033 pu/mm, P = 0.010], and was significantly steeper in those developing clinically definite multiple sclerosis within 2 years compared to those who did not (0.132 pu/mm versus 0.016 pu/mm, P = 0.020). In multivariate binary logistic regression the magnetization transfer ratio gradient was independently associated with the development of clinically definite multiple sclerosis within 2 years (magnetization transfer ratio gradient odds ratio 61.708, P = 0.023; presence of T-2 lesions odds ratio 8.500, P = 0.071). At 5 years, lesional measures overtook magnetization transfer ratio gradients as significant predictors of conversion to multiple sclerosis. The magnetization transfer ratio gradient was not significantly affected by the presence of brain lesions [T-2 lesions (P = 0.918), periventricular T-2 lesions (P = 0.580) or gadolinium-enhancing T-1 lesions (P = 0.724)]. The magnetization transfer ratio gradient also correlated with Expanded Disability Status Scale score 5 years later (Spearman r = 0.313, P = 0.027). An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis, is clinically relevant, and may arise from one or more mechanisms that are at least partly independent of lesion formation.
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