期刊
CELL CYCLE
卷 16, 期 22, 页码 2212-2219出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2017.1361072
关键词
DLX6-AS1; Long non-coding RNA; miR-26a; PTEN; Renal cell carcinoma; RCC
类别
资金
- National Natural Science Foundation of China [81173608]
Recently, long non-coding RNAs (lncRNAs) have emerged as new gene regulators and prognostic markers in several types of cancer, including renal cell carcinoma (RCC). In this study, we identified an upregulated lncRNA, DLX6-AS1, in RCC tumor tissues compared with normal kidney tissues. Our data suggested that DLX6-AS1 promoted RCC cell growth and tumorigenesis via targeting miR-26a. In addition, we observed that PTEN overexpression restored the renal cancer cell growth and also rescued the RCC tumorigenesis. In summary, we conclude that DLX6-AS1 promotes renal cell carcinoma development via regulation of miR-26a/PTEN axis.
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