期刊
ACTA OTO-LARYNGOLOGICA
卷 137, 期 7, 页码 778-785出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00016489.2016.1277263
关键词
Nutritional status; handgrip strength; anthropometry; oncology
资金
- Finnish Cultural Foundation
- Helsinki University Hospital Research Funds, Helsinki, Finland
- Swedish Childhood Cancer Foundation
- Novo Nordisk Fonden [NNF16OC0021322] Funding Source: researchfish
Conclusions: One third of the patients had cachexia with an association of significantly shorter survival. These results suggest that combining HGS and MAMA seems to be a practical method to screen cachexia in patients with head and neck cancer and may also be used when assessing their prognosis. Objectives: The aim of this study was to analyze the hypothesis that cachexia defined as both low mid-arm muscle area (MAMA) and handgrip strength (HGS) is associated with decreased survival in patients with head and neck squamous cell carcinoma (HNSCC). Methods: Sixty-five consecutive patients with primary HNSCC were enrolled prior to cancer therapy. Cachexia was defined as low handgrip strength (HGS) and low mid-arm muscle area (MAMA). Nutritional status was assessed by patient-generated subjective global assessment (PG-SGA) and sarcopenia by low MAMA. Biochemical parameters reflecting nutritional status and S-25-OHD were measured. Results: Cachexia was seen in 31% and sarcopenia in 46% of patients. Altogether, 34% of patients were malnourished. Disease-free survival was 13 months (3-62) in cachectic patients, compared with 66 months (31-78) in non-cachectic patients (p=0.009). S-25-OHD was 28nmol/l in cachectic patients, compared with 46nmol/l in non-cachectic patients (p=0.009) and prealbumin 187mg/l and 269mg/l, respectively (p<0.001).
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