期刊
DRUG DELIVERY
卷 24, 期 1, 页码 1-9出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2016.1225852
关键词
Amphotericin B; oral administration; formulation design
资金
- Shanghai Municipal Commission of Health and Family and Planning [20134318]
- Nanjing Medical University [2012NJMU243]
- Macao Science and Technology Development Fund [077/2011/A3]
Amphotericin B (AmB) remains the gold standard'' for systemic antifungal therapy, even though new drugs are emerging as the attractive antifungal agents. Since AmB has negligible oral absorption as a consequence of its unfavorable physicochemical characterizations, its use is restricted to parenteral administration which is accompanied by severe side effects. As greater understanding of the gastrointestinal tract has developed, the advanced drug delivery systems are emerging with the potential to overcome the barriers of AmB oral delivery. Much research has demonstrated that oral AmB formulations such as lipid formulations may have beneficial therapeutic efficacy with reduced adverse effects and suitable for clinical application. Here we reviewed the different formulation strategies to enhance oral drug efficacy, and discussed the current trends and future perspectives for AmB oral administration in the treatment of antifungal infections.
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