4.3 Article

A margin distance analysis of the impact of adjuvant chemoradiation on survival after pancreatoduodenectomy for pancreatic adenocarcinoma

期刊

JOURNAL OF GASTROINTESTINAL ONCOLOGY
卷 8, 期 4, 页码 696-+

出版社

AME PUBLISHING COMPANY
DOI: 10.21037/jgo.2017.04.02

关键词

Pancreatic adenocarcinoma (PDA); pancreaticoduodenectomy (PD); chemoradiotherapy (CRT); margins; adjuvant

资金

  1. NATIONAL CANCER INSTITUTE [T32CA113263] Funding Source: NIH RePORTER

向作者/读者索取更多资源

Background: The role of adjuvant chemoradiotherapy (CRT) following pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PDA) remains controversial. Recent data suggest that increased margin clearance (MC: distance between tumor and cut surface) is associated with improved survival after PD, but the role of adjuvant CRT in patients with known MC is undefined. We sought to delineate the impact of adjuvant CRT on survival based on MC following PD. Methods: Patients who underwent PD for PDA between 2002 and 2014 were retrospectively stratified into three groups based on MC: 0 mm, <= 1 mm, and >1 mm. The impact of CRT on survival in each MC group was determined by univariate and multivariate analysis. Results: Three hundred and ten patients with known MC were analyzed (0 mm =67, <= 1 mm =113, and > 1 mm = 130). Increasing MC was independently associated with improved OS (<= 1 mm, HR 0.66, 95% CI 0.46-0.96, P= 0.03; > 1 mm, HR 0.51, 95% CI 0.35-0.75, P=0.001; compared to 0 mm). Adjuvant CRT was administered to 62 patients (20%). On margin-stratified multivariate analysis, adjuvant CRT was independently associated with increased OS in patients with <= 1 mm margins (HR 0.36; 95% CI 0.18-0.69, P=0.002) but not for 0 mm and > 1 mm margins. Conclusions: This analysis suggests that the benefit of adjuvant CRT may be restricted to patients with <= 1 mm MC after PD for pancreatic cancer.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据