期刊
JOURNAL OF ABNORMAL PSYCHOLOGY
卷 126, 期 1, 页码 19-31出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/abn0000228
关键词
depression; feedback-related negativity; time-frequency decomposition; late positive potential; rumination
资金
- National Institute of Mental Health [F32 MH099801, R01 MH068376, K23 MH108752, K23 MH097786]
- Akili Interactive Labs
- BlackThorn Therapeutics
- Otsuka America Pharmaceutical
- Pfizer
- NATIONAL INSTITUTE OF MENTAL HEALTH [F32MH099801, K23MH097786, R01MH068376, K23MH108752] Funding Source: NIH RePORTER
Depression rates surge in adolescence, particularly among females. Recent findings suggest that depressed adolescents are characterized by hypersensitivity to negative outcomes and blunted responsiveness to rewards. However, our understanding of the pathophysiology and time course of these abnormalities remains limited. Due to their high temporal resolution, event-related potentials (ERPs) provide an ideal probe to investigate these processes. In the present study, healthy (n = 25) and depressed (n = 26) female adolescents (13-18 years) completed a gambling task during 128-channel ERP recording. Time-domain analyses focused on ERPs linked to initial processing of negative versus rewarding outcomes (feedback-related negativity; FRN), and later, elaborative processing (late positive potential; LPP). Additionally, time-frequency analyses were used to decompose the FRN into its 2 constituent neural signals: loss-related theta and reward-related delta activity, thereby allowing us to separately probe these 2 putative mechanisms underlying FRN abnormalities in depression. Relative to healthy adolescents, depressed youth showed potentiated FRN (loss vs. reward) responses. Time-frequency analyses revealed that this group difference in the FRN was driven by increased loss-related theta activity in depressed youth, and not by reward-related delta activity. For the LPP, healthy adolescents exhibited sustained positivity to rewards versus losses, whereas depressed adolescents showed the opposite pattern. Moreover, an enhanced LPP to losses was associated with rumination. In summary, the LPP may be a sensitive probe of depressive rumination, whereas FRN-linked theta activity may represent a neural marker of hypersensitivity to negative outcomes in depressed youth. Implications for treatment and future ERP research are discussed. General Scientific Summary Depression rates surge during adolescence, in particular among females. In the present study, depressed adolescent females exhibited increased neural reactivity to negative outcomes at 2 different processing stages, with reactivity in the later stage specifically associated with the symptom of rumination.
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