期刊
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
卷 211, 期 -, 页码 184-201出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.aanat.2017.03.002
关键词
Surfactant protein A; Surfactant protein D; Collectins; Extra-pulmonary; Complement pathway
资金
- NEI/DMEI Cellular Imaging Core Facility at OUHSC [NIH: P30EY021725]
- Histology Core Facility
- Knights Templar Eye Foundation Pediatric Ophthalmology Career Grant
- US National Institutes of Health [COBRE P20 RR017703-10]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR017703] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [P30EY021725] Funding Source: NIH RePORTER
The collectins family encompasses several collagenous Ca2+-dependent defense lectins that are described as pathogen recognition molecules. They play an important role in both adaptive and innate immunity. Surfactant proteins A and D are two of these proteins which were initially discovered in association with surfactant in the pulmonary system. The structure, immune and inflammatory functions, and genetic variations have been well described in relation to their roles, function and pathophysiology in the pulmonary system. Subsequently, these proteins have been discovered in a wide range of other organs and organ systems. The role of these proteins outside the pulmonary system is currently an active area of research. This review intends to provide a current overview of the genetics, structure and extra-pulmonary functions of the surfactant collectin proteins. (C) 2017 The Author(s). Published by Elsevier GmbH.
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