期刊
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
卷 31, 期 2, 页码 -出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hmbci-2017-0042
关键词
beige adipocyte; browning; lipolysis; macrophages; sympathetic innervation; thermogenesis; UCP1
资金
- Sao Paulo Research Foundation (FAPESP) [2015/19530-5]
- National Counsel of Science and Technology Development (CNPq) [443492/2014-0]
- FAPESP fellowship [2016/23169-9, 2016/07062-0]
Beige (or brite, brown in white) adipocytes are uncoupling protein 1 (UCP1)-positive cells residing in white adipose depots that, depending on the conditions, behave either as classic white adipocytes, storing energy as lipids, or as brown adipocytes, dissipating energy from oxidative metabolism as heat through non-shivering thermogenesis. Because of their thermogenic potential and, therefore, possible usage to treat metabolic diseases such as obesity and type 2 diabetes, beige cells have attracted the attention of many scientists worldwide aiming to develop strategies to safely recruit and activate their thermogenic activity. Indeed, in recent years, a large variety of conditions, molecules (including nutrients) and signaling pathways were reported to promote the recruitment of beige adipocytes. Despite of those advances, the true contribution of beige adipocyte thermogenesis to whole-body energy expenditure is still not completely defined. Herein, we discuss some important aspects that should be considered when studying beige adipocyte biology and the contribution to energy balance and whole-body metabolism.
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