期刊
BIPOLAR DISORDERS
卷 16, 期 7, 页码 748-755出版社
WILEY
DOI: 10.1111/bdi.12206
关键词
bipolar II disorder; default mode; dual regression; independent component analysis; medication; resting state
资金
- Young Investigator Award (CEM) from the Brain and Behaviour Research Foundation
- University of Oxford
- NIHR Oxford Biomedical Research Centre
ObjectivesDespite numerous structural and functional magnetic resonance imaging studies, the neurobiology of bipolar disorder (BD) is still incompletely understood. Resting-state functional magnetic resonance imaging (rsFMRI) allows for the study of intrinsic functional connections between brain areas, which may reflect the pathophysiology of BD. Most previous rsFMRI studies conducted in BD have included a majority of medicated patients, making simple interpretation with respect to pathophysiology difficult. MethodsParticipants were 15 antipsychotic agent- and mood-stabilizer-naive young adults with bipolar II disorder (BD-II), and 20 healthy controls group-matched for gender, age, and cognitive ability. Independent component analysis (ICA) was used to identify eight commonly studied resting-state networks (RSNs). Between-group comparisons were conducted using dual regression and corrected for family-wise error (FWE) across space and the number of components (pFWE<0.05). ResultsIn comparison to controls, participants with BD-II had increased coherence across several brain regions, including the bilateral insula and putamen, across a temporo-insular network. No between-group differences in engagement of the default mode network were found. ConclusionsThis was the first ICA-based rsFMRI study conducted among unmedicated individuals with BD. Given the young age (mean=23years) and antipsychotic agent- and mood-stabilizer-naive status of our participants with BD-II, temporo-insular functional connectivity is a candidate vulnerability marker for BD. Further work is needed to relate resting-state differences to detailed understanding of pathophysiology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据