期刊
BIPOLAR DISORDERS
卷 16, 期 1, 页码 48-57出版社
WILEY
DOI: 10.1111/bdi.12151
关键词
BDNF; bipolar disorder; estrogen; inflammation; menopause; oxidative stress; postpartum; pregnancy; premenstrual; progesterone
资金
- Alternative Funding Plan Innovations Award
- Canadian Institutes of Health Research
- Hamilton Health Sciences Foundation
- Ontario Mental Health Foundation
- Society for Women's Health Research
- Eli Lilly Co.
- Pfizer
ObjectivesPrevious studies have suggested that women with bipolar disorder are at higher risk for mood episodes during periods of intense hormonal fluctuation (e.g., premenstrual, postpartum, perimenopause). There is converging literature showing that estrogen and progesterone can modulate neurotransmitter systems and intracellular signaling pathways known to be affected by mood stabilizing agents. Here, we critically review clinical aspects of reproductive cycle events in women with bipolar disorder and preclinical studies, with a focus on the functional interactions between sex hormones and biomarkers of neuroprotection and neurodegeneration that are thought to be involved in the neurobiology of bipolar disorder: brain-derived neurotrophic factor, oxidative stress, and inflammation. MethodsA MedLine search using estrogen, progesterone, brain-derived neurotrophic factor, oxidative stress, and inflammation as key words was conducted. ResultsData showed that estrogen and progesterone closely interact with brain-derived neurotrophic factor, oxidative stress, and inflammation pathways. ConclusionsThis relationship between sex hormones and the pathways of neuroprotection/neurodegeneration may be relevant to the psychopathological aspects of bipolar disorder in women.
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