期刊
BIPOLAR DISORDERS
卷 15, 期 4, 页码 440-445出版社
WILEY
DOI: 10.1111/bdi.12068
关键词
amygdala; bipolar disorder; imaging genetics; reward processing; ventral striatum
资金
- Eli Lilly Co.
- Janssen McNeil
- Medice
- Novartis
- Shire
- UCB
- German Federal Ministry of Education and Research
- AstraZeneca
- Eli Lilly Co
- Janssen-Cilag
- Bristol-Myers Squibb
- German Research Foundation
- Bernstein Center for Computational Neuroscience Berlin (German Federal Ministry of Education and Research)
- MRC [G0901858] Funding Source: UKRI
- Medical Research Council [G9817803B, G0901858] Funding Source: researchfish
Objectives Bipolar disorder is a severe mood disorder, which normally begins during adolescence or early adulthood and has a heritability of up to 80%. The largest genome-wide association analysis of bipolar disorder recently identified a new genome-wide associated variant in OZD4 (rs12576775). The aim of the present study was to further elucidate the role of this risk variant in the disease process using an imaging genetics approach. As increased amygdala and striatal responses during the processing of reward and emotion are characteristic for bipolar disorder patients, it was tested whether the risk variant has an influence on this endophenotype in healthy adolescents. Methods We examined the impact of the risk variant rs12576775 on functional magnetic resonance imaging data in an adolescent sample (N=485). Differential activation between carriers of the risk allele (G-allele) and homozygous A-allele carriers in the amygdala and the striatum during a modification of the monetary incentive delay task (examining reward) and a face task (examining emotion) was analyzed. Results Carriers of the risk allele showed an increased blood oxygen level-dependent response in the amygdala during reward sensitivity (p=0.05) and reward expectation (p<0.05) but not during the face task. No significant group differences were found in the striatum during both reward and emotion processing. Conclusion Our results indicate that the ODZ4 risk variant influences reward processing in the amygdala. Alterations in the processing of emotion may have different underlying mechanisms and need to be further examined.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据