期刊
BIPOLAR DISORDERS
卷 12, 期 8, 页码 851-858出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1399-5618.2010.00877.x
关键词
aged; bipolar disorder; cognition
资金
- Public Health Service [K23 MH 073772, U01 MH68846, U01 MH70948, U01 MH068848, U01 MH68847, U01 MH74511, U01 MH68844, U01 MH74091]
- GlaxoSmithKline
- National Institute of Health
- Canadian Institutes for Health Research
- AstraZeneca
- Bristol-Myers Squibb
- Corcept
- Forest
- Janssen
- Pfizer
- Wyeth
- Cyberonics
- Stanley Foundation
- National Institute of Mental Health
- Suicide Prevention Internationals
- Mental Illness Research, Education and Clinical Center
- Cephalon
- American Foundation for Suicide Prevention
- NARSAD
- Evotec
- Roche
- Eli Lilly Co.
- Elan
- Novartis
- Sanofi
- Eisai
Objectives: We describe the cognitive function of older adults presenting with bipolar disorder (BD) and mania and examine whether longer lifetime duration of BD is associated with greater cognitive dysfunction. We also examine whether there are negative, synergistic effects between lifetime duration of BD and vascular disease burden on cognition. Methods: A total of 87 nondemented individuals with bipolar I disorder, age 60 years and older, experiencing manic, hypomanic, or mixed episodes, were assessed with the Dementia Rating Scale (DRS) and the Framingham Stroke Risk Profile (FSRP) as a measure of vascular disease burden. Results: Subjects had a mean (SD) age of 68.7 (7.1) years and 13.6 (3.1) years of education; 50.6% (n = 44) were females, 89.7% (n = 78) were white, and 10.3% (n = 9) were black. They presented with overall and domain-specific cognitive impairment in memory, visuospatial ability, and executive function compared to age-adjusted norms. Lifetime duration of BD was not related to DRS total score, any other subscale scores, or vascular disease burden. FSRP scores were related to the DRS memory subscale scores, but not total scores or any other domain scores. A negative interactive effect between lifetime duration of BD and FSRP was only observed with the DRS construction subscale. Conclusions: In this study, lifetime duration of BD had no significant relationship with overall cognitive function in older nondemented adults. Greater vascular disease burden was associated with worse memory function. There was no synergistic relationship between lifetime duration of BD and vascular disease burden on overall cognition function. Addressing vascular disease, especially early in the course of BD, may mitigate cognitive impairment in older age.
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