期刊
SIGNAL TRANSDUCTION AND TARGETED THERAPY
卷 2, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sigtrans.2017.44
关键词
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资金
- National Natural Science Foundation of China [81372621, 81572361, 81502398, 81602635]
- Zhejiang Province Preeminence Youth Fund [LR16H160001]
- Zhejiang Natural Sciences Foundation [Q16H160019]
The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFK-2/FBPase 3, PFKFB3) has advanced considerably since its initial identification in human macrophages in the mid-1990s. As a vital regulator of glycolysis, accumulating studies have suggested that PFKFB3 is associated with many aspects of cancer, including carcinogenesis, cancer cell proliferation, vessel aggressiveness, drug resistance and tumor microenvironment. In this review, we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues. Ubiquitous PFKFB3 has emerged as a potential target for anti-neoplastic therapy.
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