期刊
ORGANIC COMMUNICATIONS
卷 10, 期 2, 页码 90-98出版社
ACG PUBLICATIONS
DOI: 10.25135/acg.oc.12.16.12.453
关键词
1,3-Phenylene-bis-N-acetylpyrazoles; 1,3-phenylene-bis-N-phenylpyrazoles; antibacterial activity
资金
- TUBITAK [2209]
The 1,1'-(5,5'-(1,3-phenylene) bis(3-aryl-4,5-dihydro-1H-pyrazole-5,1-diyl)) di-ethanone (5a-e) and 1,3-bis(1-phenyl-3-(aryl)-4,5-dihydro-1H-pyrazol-5-yl) benzene (6a-e) were synthesized by addition of hydrazine hydrate and/or phenylhydrazine to 1,3-phenylene-bis-chalcone derivatives (3a-e), respectively. The structures of obtained compounds (5a-e and 6a-e) were characterized using the spectroscopic methods (NMR, IR) and elemental analysis. Addition, the in vitro antibacterial activities of compounds (5a-e) was tested against the five human pathogenic bacteria. Gentamycin and Fluconazole were used as positive control. The results were given as inhibition zone (mm) and the compounds 5d and 5e showed the same activity with standard (Fluconazole) against C. albinas.
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