期刊
EYE AND VISION
卷 4, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s40662-017-0088-4
关键词
Carotenoids; Diabetes mellitus; Visual function; Multifocal electroretinography; Optical coherence tomography
Background: Diabetic retinopathy is a major cause of visual impairment and blindness among working-age people worldwide. The aim of our study was to investigate the effects of a carotenoid supplementation on retinal thickness and macular function of patients with diabetes using optical coherence tomography (OCT) and multifocal electroretinography (mfERG). Methods: A retrospective study of one hundred and twenty eyes of sixty patients age between 40 and 60 years with non-insulin dependent type 2 diabetes mellitus without diabetic retinopathy who underwent OCT and mfERG and took vitamin supplements for a period of two years. Patients received a carotenoid supplement containing lutein (10 mg), zeaxanthin (2 mg) and meso-zeaxanthin (10 mg) once a day for two years. The thickness of the fovea was evaluated using OCT and the macular function was tested by mfERG. Results: OCT showed an increase in the central foveal thickness and mfERG revealed increased retinal response density within the central 13 degrees surrounding the fovea (rings 1 to 3) at two years after the onset of carotenoids supplement intake. Conclusion: The use of carotenoid supplements may be of benefit for improving visual function of type 2 diabetes patients. However, further study is needed to assess the treatment's long-term efficacy.
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