期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 36, 页码 30458-30469出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b09633
关键词
multifunctional polymeric nanoparticle; photothermal therapy; photoacoustic imaging; magnetic resonance imaging; gadolinium ion
资金
- National Basic Research Program of China [2015CB932200]
- National Natural Science Foundation of China [21574064, 21674048, 21605088, 61378081]
- Natural Science Foundation of the Jiangsu Higher Education Institutions [16KJB150031]
- Synergetic Innovation Center for Organic Electronics and Information Displays
- Natural Science Foundation of Jiangsu Province of China [BK20160884, BM2012010, NY211003]
Developing versatile and easily prepared nanomaterials with both imaging and therapeutic properties have received significant attention in cancer diagnostics and therapeutics. Here, we facilely fabricated Gd3+-chelated poly(isobutylene-alt-maleic anhydride) (PMA) framework pendent with perylene-3,4,9,10-tetracarboxylic diimide (PDI) derivatives and poly(ethylene glycol) (PEG) as an efficient theranostic platform for dual-modal photoacoustic imaging (PAI) and magnetic resonance imaging (MRI)-guided photothermal therapy. The obtained polymeric nanoparticles (NPs) chelated with Gd3+ (PMAPDIPEGGd NPs) exhibited a high T-1 relaxivity coefficient (13.95 mM(1) s(1)) even at the higher magnetic fields. After 3.5 h of tail vein injection of PMAPDIPEGGd NPs, the tumor areas showed conspicuous enhancement in both photoacoustic signal and T-1-weighted MRI intensity, indicating the efficient accumulation of PMAPDIPEGGd NPs owing to the enhanced permeation and retention effect. In addition, the excellent tumor ablation therapeutic effect in vivo was demonstrated with living mice. Overall, our work illustrated a straightforward synthetic strategy for engineering multifunctional polymeric nanoparticles for dual-modal imaging to obtain more accurate information for efficient diagnosis and therapy.
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