期刊
BIOTECHNOLOGY LETTERS
卷 36, 期 5, 页码 961-968出版社
SPRINGER
DOI: 10.1007/s10529-014-1465-x
关键词
Antibacterial activity; Hydroxyapatite (porous); Mesoporous bioactive glass; Orbital implant; Porous hydroxyapatite; Sustained drug release
资金
- Natural Science Foundation of China [81070756, 51102211]
- National Twelfth Five-Year'' Plan for Science & Technology Support of China [2012BAI08B01]
- Zhejiang Provincial Program for Cultivation of High-Level Innovative Health Talents
Anophthalmic orbit restoration with artificial implants is usually accompanied with the risks of bacterial penetration and implant exposure. Here, we develop a facile evaporation-inducing self-assembly approach to modify the porous hydroxyapatite (pHA) orbital implants by using sol-gel derived CuO-containing mesoporous bioactive glass (Cu-MBG). The Cu-MBG coatings with 0-5 mol% CuO were prepared in the pore wall of pHA by immersion-evaporation-ageing route in the sol precursor of Cu-MBG. Brunauer-Emmett-Teller and Barrette-Joyner-Halenda analyses showed that the specific surface area and pore volume were slightly decreased with increasing CuO content, while the Cu-MBG-modified pHA maintained a sustained release of ofloxacin and significantly inhibited the bacterial viability (Staphylococcus aureus and Escherichia coli). These studies demonstrate that the Cu-MBG modification provides an effective and facile strategy to endow combined biological performances of pHA orbital implants and potentially reduce implant-related side effects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据