期刊
BIOTECHNOLOGY LETTERS
卷 34, 期 7, 页码 1375-1384出版社
SPRINGER
DOI: 10.1007/s10529-012-0900-0
关键词
Bone marrow-derived mesenchymal stem cells; Bone morphogenetic protein-2; Bone tissue engineering; Polycaprolactone scaffold; 3D plotting system
资金
- National Research Foundation of Korea [KRF-2008-313-E00356]
- National Research Foundation of Korea [2008-313-E00356] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The three-dimensional (3D) plotting system is a rapidly-developing scaffold fabrication method for bone tissue engineering. It yields a highly porous and inter-connective structure without the use of cytotoxic solvents. However, the therapeutic effects of a scaffold fabricated using the 3D plotting system in a large segmental defect model have not yet been demonstrated. We have tested two hypotheses: whether the bone healing efficacy of scaffold fabricated using the 3D plotting system would be enhanced by bone marrow-derived mesenchymal stem cell (BMSC) transplantation; and whether the combination of bone morphogenetic protein-2 (BMP-2) administration and BMSC transplantation onto the scaffold would act synergistically to enhance bone regeneration in a large segmental defect model. The use of the combined therapy did increase bone regeneration further as compared to that with monotherapy in large segmental bone defects.
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