期刊
BIOTECHNOLOGY LETTERS
卷 34, 期 9, 页码 1607-1616出版社
SPRINGER
DOI: 10.1007/s10529-012-0944-1
关键词
AMP-activated protein kinase; Damulins; Fat oxidation; Gynostemma pentaphyllum; Obesity
资金
- Plant Diversity Research Center of the 21st Century Frontier Research Program [PF06212-00]
- Ministry of Science and Technology
- Ministry of Health and Welfare, Republic of Korea [A111345]
Gynostemma pentaphyllum is widely used in Asian countries as a herbal medicine to treat dyslipidemia, type 2 diabetes and inflammation. An ethanol extract of G. pentaphyllum lessened obesity by activating AMP-activated protein kinase (AMPK). The levels of damulins A and B, components responsible for AMPK activation in the extract, were increased by autoclaving in a time-dependent manner. Heat-processed G. pentaphyllum extract, actiponin containing damulins A (0.93 %, w/w) and B (0.68 %, w/w), significantly stimulated fat oxidation and glucose uptake via AMPK activation in L6 myotube cells. Oral administration of actiponin to ob/ob mice for 8 weeks decreased body weight gain, liver weight, and blood cholesterol levels with AMPK activation in the soleus muscle. Our results demonstrate the beneficial effect of G. pentaphyllum on improving obesity and have elucidated the underlying molecular mechanisms.
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