期刊
BIOTECHNOLOGY LETTERS
卷 34, 期 1, 页码 9-17出版社
SPRINGER
DOI: 10.1007/s10529-011-0741-2
关键词
Buthus martensii Karsch CT; beta-Catenin; Glioma; Lithium chloride; Matrix metalloproteinase-2
资金
- National Natural Science Foundation of China [30700534, 31071924]
- Natural Science Foundation of Shanxi Province [2008021039, 2010011040-1, 2009011059-3]
- Shanxi Scholarship Council of China
Therapies for high-grade gliomas (HHG) that have strong tendency of infiltration and resistance to chemotherapies are currently unavailable. Here, we report that lower-dose combination therapy of Buthus martensii Karsch (BmK) CT, a type of scorpion toxin peptide, and LiCl, clinically used as mood stabilizer, could synergistically inhibit the migration, invasion and proliferation of C6 glioma cells. The decreased invasiveness of C6 glioma cells was accompanied by inhibited activation, catalytic activity and/or expression of matrix metalloproteinase-2. Moreover, TOPfalsh luciferase reporter and immunofluorescence staining showed altered localization pattern of beta-catenin at the leading edge of 2D scratch. Our results suggested that the combination treatment of lithium and BmK CT may constitute a novel and potential strategy for HHG therapy.
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