期刊
BIOTECHNOLOGY LETTERS
卷 34, 期 4, 页码 779-787出版社
SPRINGER
DOI: 10.1007/s10529-011-0819-x
关键词
Bone regeneration; Dexamethasone; Guided bone regeneration; Membrane; Poly(lactic-co-glycolic acid)
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [R13-2008-010-00000-0]
- National Research Foundation of Korea [2010-0029518] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A novel barrier membrane composed of poly(lactic-co-glycolic acid) particles loaded with dexamethasone (DEX) as a bioactive molecule was produced via a modified nanoprecipitation method without any mixing. The particle membranes had a bilayer structure: one side was smooth and had a compact surface that was connected to larger particles, while the opposite side was rough, porous and connected to smaller particles. Additionally, a cross-section of the particle membrane had a porous structure with nano and micro sized irregular pores. Process optimization revealed that NaCl concentration in the water phase, with acetone as solvent and water as a non-solvent, played critical roles in determining the properties of the particle membranes, such as DEX encapsulation efficiency, thickness and surface morphologies of the particle membranes. A novel barrier membrane containing DEX using polymer particle drug capture technology has been successfully developed.
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