期刊
ACS NANO
卷 11, 期 9, 页码 9103-9111出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b03857
关键词
coordination polymer nanodots; chelator-free Cu-64-labeling; positron emission tomography imaging radiotherapy; rapid renal clearance
类别
资金
- National Basic Research Programs of China (973 Program) [2016YFA0201200]
- National Natural Science Foundation of China [51525203, 51572180, 51302180]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- University of Wisconsin-Madison
- National Institutes of Health [NIBIB/NCI 1R01CA169365, 1R01CA205101, 1R01EB021336, P30CA014520]
- American Cancer Society [125246-RSG-13-099-01-CCE]
- NATIONAL CANCER INSTITUTE [R01CA205101, R01CA169365, P30CA014520] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB021336] Funding Source: NIH RePORTER
Developing tumor-homing nanoparticles with integrated diagnostic and therapeutic functions, and meanwhile could be rapidly excreted from the body, would be of great interest to realize imaging guided precision treatment of cancer. In this study, an ultrasmall coordination polymer nanodot (CPN) based on the coordination between tungsten ions (W-VI) and gallic acid (W-GA) was developed via a simple method. After polyethylene glycol (PEG) modification, PEGylated W-GA (W-GA-PEG) CPNs with an ultrasmall hydrodynamic diameter of 5 nm were rather stable in various physiological solutions. Without the need of chelator molecules, W-GA-PEG CPNs could be efficiently labeled with radioisotope Cu-64(2+), enabling positron emission tomography (PET) imaging, which reveals efficient tumor accumulation and rapid renal clearance of W-GA-PEG CPNs upon intravenous injection. Utilizing the radio-sensitizing function of tungsten with strong X-ray absorption, such W-GA-PEG CPNs were able to greatly enhance the efficacy of cancer radiotherapy in inhibiting the tumor growth. With fast clearance and little long-term body retention, those W-GA-PEG CPNs exhibited no appreciable in vivo toxicity. This study presents a type of CPNs with excellent imaging and therapeutic abilities as well as rapid renal clearance behavior, promising for further clinic translation.
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