期刊
BIOTECHNOLOGY LETTERS
卷 31, 期 8, 页码 1265-1267出版社
SPRINGER
DOI: 10.1007/s10529-009-0010-9
关键词
Cathelicidins; Lactoferrin; Lysozyme; Nisin; Polymyxin
Synergistic effects of ovine-derived cathelicidins SMAP29 and OaBac5mini with the antimicrobials polymyxin B, lysozyme, nisin and lactoferrin were investigated against E. coli O157:H7 and S. aureus 1056 MRSA. Lysozyme showed synergy against E. coli O157:H7 with SMAP29, polymyxin B and lactoferrin. Synergy was also found between SMAP29 and lactoferrin against this host. Against S. aureus 1056 MRSA, lysozyme showed synergy with OaBac5mini, polymyxin B and nisin, while synergy was also found between nisin and OaBac5mini and polymyxin B. Other combinations of the antimicrobials were either additive or non-synergistic.
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