期刊
BIOTECHNOLOGY JOURNAL
卷 9, 期 6, 页码 719-726出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201300385
关键词
Biopharmaceuticals; Bioprocess development; Hybrid modeling; Process analytical technology; Quality by design
资金
- Faculty of Engineering, University of Porto
- Faculty of Science and Technology, University Nova de Lisboa
- Fundacao para a Ciencia e a Tecnologia [SFRH/BPD/84573/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/84573/2012] Funding Source: FCT
This report highlights the drivers, challenges, and enablers of the hybrid modeling applications in biopharmaceutical industry. It is a summary of an expert panel discussion of European academics and industrialists with relevant scientific and engineering backgrounds. Hybrid modeling is viewed in its broader sense, namely as the integration of different knowledge sources in form of parametric and nonparametric models into a hybrid semi-parametric model, for instance the integration of fundamental and data-driven models. A brief description of the current state-of-the-art and industrial uptake of the methodology is provided. The report concludes with a number of recommendations to facilitate further developments and a wider industrial application of this modeling approach. These recommendations are limited to further exploiting the benefits of this methodology within process analytical technology (PAT) applications in biopharmaceutical industry.
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