Processing and characterization of laser sintered hydroxyapatite scaffold for tissue engineering

The sintering processing of hydroxyapatite (HAP) powder was studied using selective laser sintering for bone tissue engineering. The effect of laser energy density on the microstructure, phase composition and mechanical properties of the sintered samples was investigated. The results indicate that the average grain size increases from 0.211 +/- 0.039 to 0.979 +/- 0.133 mu m with increasing the laser energy density from 2.0 to 5.0 J/mm(2). The maximum value of Vickers hardness and fracture toughness were 4.0 +/- 0.13 Gpa and 1.28 +/- 0.033 MPam(1/2), respectively, when the laser energy density was 4.0 J/mm(2). The XRD results indicated that the nano-HAP was decomposed into TCP with the laser energy density of above 4.0 J/mm(2). In vitro bioactivity after soaking in simulated body fluid (SBF) for 3 similar to 12 days showed that a bone-like apatite layer on the surface of the sintered samples. It indicated that the HAP scaffold possesses favorable mechanical properties and bioactivity, and may be used for bone tissue engineering.