期刊
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
卷 18, 期 3, 页码 520-527出版社
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
DOI: 10.1007/s12257-012-0508-1
关键词
hydroxyapatite; selective laser sintering; laser energy density; mechanical properties; biodegradation
资金
- Natural Science Foundation of China [51222506, 81000972, 81102045]
- foundation for the author of national excellent doctoral dissertation of PR China [201032]
- Program for New Century Excellent Talents in University [NCET-10-0792, NCET-12-0544]
- Fundamental Research Funds for the Central Universities [2011JQ005, 2012QNZT015]
- Fok Ying-Tong Education Foundation, China [131050]
- Open Research Fund of State Key Laboratory of Transient Optics and Photonics, Chinese Academy of Sciences
- Open-End Fund for the Valuable and Precision Instruments of Central South University
- Hunan Provincial Natural Science Foundation of China [12JJ4067]
- Postdoctoral Science Foundation of Central South University
The sintering processing of hydroxyapatite (HAP) powder was studied using selective laser sintering for bone tissue engineering. The effect of laser energy density on the microstructure, phase composition and mechanical properties of the sintered samples was investigated. The results indicate that the average grain size increases from 0.211 +/- 0.039 to 0.979 +/- 0.133 mu m with increasing the laser energy density from 2.0 to 5.0 J/mm(2). The maximum value of Vickers hardness and fracture toughness were 4.0 +/- 0.13 Gpa and 1.28 +/- 0.033 MPam(1/2), respectively, when the laser energy density was 4.0 J/mm(2). The XRD results indicated that the nano-HAP was decomposed into TCP with the laser energy density of above 4.0 J/mm(2). In vitro bioactivity after soaking in simulated body fluid (SBF) for 3 similar to 12 days showed that a bone-like apatite layer on the surface of the sintered samples. It indicated that the HAP scaffold possesses favorable mechanical properties and bioactivity, and may be used for bone tissue engineering.
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