期刊
ORGANIC CHEMISTRY FRONTIERS
卷 5, 期 23, 页码 3382-3390出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00979a
关键词
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资金
- Department of Henan Province Natural Science and Technology Foundation [172102210222, 172102210225]
- Natural Science Foundation in Henan Province Department of Education [17A150005, 17A150007]
- Program for Innovative Research Team from Zhengzhou [131PCXTD605]
- Project of Youth Backbone Teachers of Henan University of Technology [2016003]
An efficient copper-catalyzed protocol for the synthesis of hydroxyl-containing quinoxalin-2(1H)-ones from the radical reaction of quinoxalin-2(1H)-ones with alcohols was developed with moderate to good yields. Quinoxalin-2(1H)-ones were coupled with alkyl radicals through direct catalytic functionalization of the sp(3) C-H bond of alcohols. The methodology demonstrates a broad substrate scope, excellent functional group tolerance, high atom economy and high efficiency, thus enabling the preparation of diverse potentially valuable hydroxyl-containing quinoxalin-2(1H)-ones.
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