期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1395, 期 -, 页码 32-40出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2015.03.066
关键词
Methacrylate ester; Divinylbenzene; Polymeric monoliths; Solid-phase microextraction (SPME); Non-steroidal anti-inflammatory drugs (NSAIDs)
资金
- Ministry of Science and Technology of Taiwan [MOST 103-2632M-033-001-MY3, NSC-101-2113M-033-002-MY3]
- Chung Yuan Christian University
In this study, an organic polymer monolithic columns, which were prepared via in situ polymerization of alkyl methacrylate-ester (AMA), divinylbenzene (DVB) and vinylbenzyl trimethylammonium chloride (VBTA, charged monomer), were developed as adsorbent for solid-phase microextraction (SPME). Different parameters affecting the extraction efficiency for nine (9) non-steroidal anti-inflammatory drugs (NSAIDs) such as the ratio of the stearyl methacrylate (SMA) to DVB monomer, column length, sample pH, extraction flow rate and desorption solvent were investigated to obtain the optimal SPME condition. Also, the permeability for each poly(AMA-DVB-VBTA) monolithic column was investigated by adding porogenic solvent (poly(ethylene glycol), PEG). Using the optimized condition, a series of AMA-based poly(AMA-DVB-VBTA) monolith columns were developed to determine the effect the extraction efficiency of NSAIDs by varying the alkyl chain length of the methacrylate ester (methyl-, butyl-, octyl-, or lauryl-methacrylate; (MMA, BMA, OMA, LMA)). Results showed that decreasing the AMA chain length increases the extraction efficiency of some NSAIDs (i.e. sulindac (sul), naproxen (nap), ketoprofen (ket) and indomethacin (idm)). Among the poly(AMA-DVB-VBTA) monolithic columns, poly(BMA-DVB-VBTA) showed a highly repeatable extraction efficiency for NSAIDs with recoveries ranging from 85.0 to 100.2% with relative standard deviation (RSD) less than 6.8% (n =3). The poly(BMA-DVB-VBTA) can also be reused for at least 50 times without any significant effect in extraction efficiency for NSAIDs. Finally, using the established conditions, the poly(BMA-DVB-VBTA) was used to extract trace-level NSAIDs (100 mu g L-1) in river water with good recoveries ranging from 75.8 to 90.8% (RSD <14.9%). (C) 2015 Elsevier B.V. All rights reserved.
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